Downstream Processing Market by Product (Membrane Adsorbents, Chromatography Columns and Resins, Filters, Others), By Technique, Purification Techniques (Gel Chromatography, Ion Exchange Chromatography, Affinity Chromatography, Hydrophobic Interaction Chromatography), Solid-Liquid Separation (Filtration, Centrifugation, Concentration/Clarification), By Application (Vaccines Production, Monoclonal Antibodies Production, Insulin Production, Erythropoietin Production, Immunoglobulin Production, Others), By End User (Biopharmaceutical Manufacturers, Contract Manufacturing Organizations, Others) and Geography (North America, Latin America, Europe, Middle East and Africa, Asia Pacific).


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The global downstream processing market size was estimated at USD 21.9 billion in 2021 and is expected to expand at a compound annual growth rate (CAGR) of 15.6% from 2022 to 2028. Downstream processing is the process of recovery and purification of the biosynthetic products. Biosynthetic products particularly pharmaceuticals, from natural sources such as plant or animal tissue or fermentation broth. Downstream processing market may also include recycling of salvageable components and proper treatment of waste. Furthermore, downstream processing is important step in manufacturing of hormones, antibiotics, antibodies, and vaccines. Stages include removal of insoluble, product isolation, product purification, product polishing and few recovery methods may be considered.  The market is expected to grow at significant rates owing to the rise in demand for biopharmaceutical products. The market is consolidated due to presence of the many companies competing with product innovations and advancements. Companies are focusing on the R&D and new product launches to increase their product portfolio. For instance, in November 2012, Asahi Kasie Medical Co. Ltd. Has launched 5 L QyuSpeed D membrane adsorbers, designed specifically for removal of impurities in bioprocessing. In the product segment, chromatographic columns and resins are expected to have significant growth rate owing to the technological advancements in chromatography techniques and new product launches.

Downstream Processing Market Summary

Study Period


Base Year




Largest Market

North America

Fastest Growing Market

Market Dynamics Dynamics

The market is mainly driven by the rise in R&D investment by the companies and government in the biopharmaceutical industry to produce more effective biopharmaceuticals. In addition, propelling demand for biopharmaceuticals due to the rising prevalence of communicable diseases and chronic diseases such as cancer boosting the market growth over the forecast period. Furthermore, technological developments in purification technology and need for highly pure biopharmaceuticals such as vaccines bolstering the global downstream processing market. However, lack of skilled professionals, high cost of devices and regulatory procedures are expected to hamper the market during the forecast period.

Key Features of the Reports

  • The report provides granular level information about the market size, regional market share, historic market (2018 to 2022) and forecast (2023 to 2029)
  • The report covers in-detail insights about the competitor’s overview, company share analysis, key market developments, and their key strategies
  • The report outlines drivers, restraints, unmet needs, and trends that are currently affecting the market
  • The report tracks recent innovations, key developments and startup’s details that are actively working in the market
  • The report provides plethora of information about market entry strategies, regulatory framework and reimbursement scenario
  • The report analyses the impact of socio-political environment through PESTLE Analysis and competition through Porter’s Five Force Analysis in addition to recent technology advancements and innovations in the market

Downstream Processing Market Segmentation

by Product Type
  • Membrane Adsorbents
  • Chromatography Columns and Resins
  • Filters
  • Others
by Technique
  • Purification Techniques
    • Gel Chromatography
    • Ion Exchange Chromatography
    • Affinity Chromatography
    • Hydrophobic Interaction Chromatography
    • Solid-Liquid Separation
      • Filtration
      • Centrifugation
  • Concentration/Clarification
By Application
  • Vaccine Production
  • Monoclonal Antibodies Production
  • Insulin Production
  • Erythropoietin Production
  • Immunoglobulin Production
  • Others
By End User
  • Biopharmaceutical Manufacturers
  • Contract Manufacturing Organizations
  • Others

Frequently Asked Questions

2021 is the base year and 2028 is the forecast year.

The report covers the five regions and 15+ countries market data: North America (United States, Canada), Europe (Germany, France, Italy, Spain, and United Kingdom (UK), Asia Pacific (China, India, Japan, Australia & New Zealand), Latin America (Brazil, Mexico, Argentina) and Middle East and Africa (Saudi Arabia, United Arab Emirates, South Africa).

In our report, we provide 12-15 market players’ information into the report. However, based on the client’s request we will provide additional country and regional market players information as well.

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  • Boehringer Ingelheim GmbH (Germany)
  • 3M Company (U.S.)
  • Eppendorf AG (Germany)
  • Danaher Corporation (U.S.)
  • General Electric (U.S.)
  • Finesse Solutions, Inc. (Thermo Fisher Scientific) (U.S.)
  • Merck KGaA (Germany)
  • Lonza Group AG (Switzerland)