Downstream Processing Market by Product (Membrane Adsorbents, Chromatography Columns and Resins, Filters, Others), By Technique, Purification Techniques (Gel Chromatography, Ion Exchange Chromatography, Affinity Chromatography, Hydrophobic Interaction Chromatography), Solid-Liquid Separation (Filtration, Centrifugation, Concentration/Clarification), By Application (Vaccines Production, Monoclonal Antibodies Production, Insulin Production, Erythropoietin Production, Immunoglobulin Production, Others), By End User (Biopharmaceutical Manufacturers, Contract Manufacturing Organizations, Others) and Geography (North America, Latin America, Europe, Middle East and Africa, Asia Pacific).    

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Downstream Processing Market size was estimated at USD 23.9 billion in 2022 and is poised to grow at a significant CAGR of 15.6% from 2023- 2029. Downstream processing is the process of recovery and purification of the biosynthetic products. Biosynthetic products particularly pharmaceuticals, from natural sources such as plant or animal tissue or fermentation broth. Downstream processing market may also include recycling of salvageable components and proper treatment of waste. Furthermore, downstream processing is important step in manufacturing of hormones, antibiotics, antibodies, and vaccines. Stages include removal of insoluble, product isolation, product purification, product polishing and few recovery methods may be considered. The market is expected to grow at significant rates owing to the rise in demand for biopharmaceutical products. The market is consolidated due to presence of the many companies competing with product innovations and advancements. Companies are focusing on the R&D and new product launches to increase their product portfolio.

Downstream Processing Market Key Developments : 

  • In November 2012, Asahi Kasie Medical Co. Ltd. Has launched 5 L QyuSpeed D membrane adsorbers, designed specifically for removal of impurities in bioprocessing. In the product segment, chromatographic columns and resins are expected to have significant growth rate owing to the technological advancements in chromatography techniques and new product launches.

Downstream Processing Market Summary

Study Period

2024-2030

Base Year

2023

CAGR

15.6%

Largest Market

North America

Fastest Growing Market

Asia-Pacific
Downstream Processing Market Dynamics

The market is mainly driven by the rise in R&D investment by the companies and government in the biopharmaceutical industry to produce more effective biopharmaceuticals. In addition, propelling demand for biopharmaceuticals due to the rising prevalence of communicable diseases and chronic diseases such as cancer boosting the market growth over the forecast period. Furthermore, technological developments in purification technology and need for highly pure biopharmaceuticals such as vaccines bolstering the global downstream processing market. However, lack of skilled professionals, high cost of devices and regulatory procedures are expected to hamper the market during the forecast period.

Downstream Processing Market Segmentation

By Product Type
  • Membrane Adsorbents
  • Chromatography Columns and Resins
  • Filters
  • Others
By Technique
  • Purification Techniques
    • Gel Chromatography
    • Ion Exchange Chromatography
    • Affinity Chromatography
    • Hydrophobic Interaction Chromatography
    • Solid-Liquid Separation
      • Filtration
      • Centrifugation
  • Concentration/Clarification
By Application
  • Vaccine Production
  • Monoclonal Antibodies Production
  • Insulin Production
  • Erythropoietin Production
  • Immunoglobulin Production
  • Others
By End User
  • Biopharmaceutical Manufacturers
  • Contract Manufacturing Organizations
  • Others

Frequently Asked Questions

2022 is the base year and 2029 is the forecast year.

The report covers the five regions and 15+ countries market data: North America (United States, Canada), Europe (Germany, France, Italy, Spain, and United Kingdom (UK), Asia Pacific (China, India, Japan, Australia & New Zealand), Latin America (Brazil, Mexico, Argentina) and Middle East and Africa (Saudi Arabia, United Arab Emirates, South Africa).

In our report, we provide 12-15 market players’ information into the report. However, based on the client’s request we will provide additional country and regional market players information as well.

Downstream Processing Market size was estimated at USD 23.9 billion in 2022.

The key trend in the downstream processing market is the growing adoption of single-use technologies to improve flexibility and reduce operational costs in biopharmaceutical manufacturing processes.

Key Features of the Reports

  • The report provides granular level information about the market size, regional market share, historic market (2018 to 2022) and forecast (2023 to 2029)
  • The report covers in-detail insights about the competitor’s overview, company share analysis, key market developments, and their key strategies
  • The report outlines drivers, restraints, unmet needs, and trends that are currently affecting the market
  • The report tracks recent innovations, key developments and startup’s details that are actively working in the market
  • The report provides plethora of information about market entry strategies, regulatory framework and reimbursement scenario
  • The report analyses the impact of socio-political environment through PESTLE Analysis and competition through Porter’s Five Force Analysis in addition to recent technology advancements and innovations in the market
1.Executive Summary
2.Global Downstream Processing Market Introduction 
2.1.Global Downstream Processing Market  - Taxonomy
2.2.Global Downstream Processing Market  - Definitions
2.2.1.Product Type
2.2.2.Technique
2.2.3.Application
2.2.4.End User
2.2.5.Region
3.Global Downstream Processing Market Dynamics
3.1. Drivers
3.2. Restraints
3.3. Opportunities/Unmet Needs of the Market
3.4. Trends
3.5. Product Landscape
3.6. New Product Launches
3.7. Impact of COVID 19 on Market
4.Global Downstream Processing Market Analysis, 2018-2022 and Forecast 2023-2029
4.1.  Market Analysis, 2018-2022 and Forecast, 2023-2029, (Sales Value USD Million)
4.2.  Year-Over-Year (Y-o-Y) Growth Analysis (%) 
4.3.  Market Opportunity Analysis 
5.Global Downstream Processing Market  By Product Type, 2018-2022 and Forecast 2023-2029 (Sales Value USD Million)
5.1. Membrane Adsorbents
5.1.1. Market Analysis, 2018-2022 and Forecast, 2023-2029, (Sales Value USD Million)
5.1.2. Year-Over-Year (Y-o-Y) Growth Analysis (%) and Market Share Analysis (%) 
5.1.3. Market Opportunity Analysis 
5.2. Chromatography Columns and Resins
5.2.1. Market Analysis, 2018-2022 and Forecast, 2023-2029, (Sales Value USD Million)
5.2.2. Year-Over-Year (Y-o-Y) Growth Analysis (%) and Market Share Analysis (%) 
5.2.3. Market Opportunity Analysis 
5.3. Filters
5.3.1. Market Analysis, 2018-2022 and Forecast, 2023-2029, (Sales Value USD Million)
5.3.2. Year-Over-Year (Y-o-Y) Growth Analysis (%) and Market Share Analysis (%) 
5.3.3. Market Opportunity Analysis 
5.4. Others
5.4.1. Market Analysis, 2018-2022 and Forecast, 2023-2029, (Sales Value USD Million)
5.4.2. Year-Over-Year (Y-o-Y) Growth Analysis (%) and Market Share Analysis (%) 
5.4.3. Market Opportunity Analysis 
6.Global Downstream Processing Market  By Technique, 2018-2022 and Forecast 2023-2029 (Sales Value USD Million)
6.1. Purification Techniques
6.1.1. Market Analysis, 2018-2022 and Forecast, 2023-2029, (Sales Value USD Million)
6.1.2. Year-Over-Year (Y-o-Y) Growth Analysis (%) and Market Share Analysis (%) 
6.1.3. Market Opportunity Analysis 
6.2. Concentration/Clarification
6.2.1. Market Analysis, 2018-2022 and Forecast, 2023-2029, (Sales Value USD Million)
6.2.2. Year-Over-Year (Y-o-Y) Growth Analysis (%) and Market Share Analysis (%) 
6.2.3. Market Opportunity Analysis 
7.Global Downstream Processing Market  By Application, 2018-2022 and Forecast 2023-2029 (Sales Value USD Million)
7.1. Vaccine Production
7.1.1. Market Analysis, 2018-2022 and Forecast, 2023-2029, (Sales Value USD Million)
7.1.2. Year-Over-Year (Y-o-Y) Growth Analysis (%) and Market Share Analysis (%) 
7.1.3. Market Opportunity Analysis 
7.2. Monoclonal Antibodies Production
7.2.1. Market Analysis, 2018-2022 and Forecast, 2023-2029, (Sales Value USD Million)
7.2.2. Year-Over-Year (Y-o-Y) Growth Analysis (%) and Market Share Analysis (%) 
7.2.3. Market Opportunity Analysis 
7.3. Insulin Production
7.3.1. Market Analysis, 2018-2022 and Forecast, 2023-2029, (Sales Value USD Million)
7.3.2. Year-Over-Year (Y-o-Y) Growth Analysis (%) and Market Share Analysis (%) 
7.3.3. Market Opportunity Analysis 
7.4. Erythropoietin Production
7.4.1. Market Analysis, 2018-2022 and Forecast, 2023-2029, (Sales Value USD Million)
7.4.2. Year-Over-Year (Y-o-Y) Growth Analysis (%) and Market Share Analysis (%) 
7.4.3. Market Opportunity Analysis 
7.5. Immunoglobulin Production
7.5.1. Market Analysis, 2018-2022 and Forecast, 2023-2029, (Sales Value USD Million)
7.5.2. Year-Over-Year (Y-o-Y) Growth Analysis (%) and Market Share Analysis (%) 
7.5.3. Market Opportunity Analysis 
7.6. Others
7.6.1. Market Analysis, 2018-2022 and Forecast, 2023-2029, (Sales Value USD Million)
7.6.2. Year-Over-Year (Y-o-Y) Growth Analysis (%) and Market Share Analysis (%) 
7.6.3. Market Opportunity Analysis 
8.Global Downstream Processing Market  By End User, 2018-2022 and Forecast 2023-2029 (Sales Value USD Million)
8.1. Biopharmaceutical Manufacturers
8.1.1. Market Analysis, 2018-2022 and Forecast, 2023-2029, (Sales Value USD Million)
8.1.2. Year-Over-Year (Y-o-Y) Growth Analysis (%) and Market Share Analysis (%) 
8.1.3. Market Opportunity Analysis 
8.2. Contract Manufacturing Organizations
8.2.1. Market Analysis, 2018-2022 and Forecast, 2023-2029, (Sales Value USD Million)
8.2.2. Year-Over-Year (Y-o-Y) Growth Analysis (%) and Market Share Analysis (%) 
8.2.3. Market Opportunity Analysis 
8.3. Others
8.3.1. Market Analysis, 2018-2022 and Forecast, 2023-2029, (Sales Value USD Million)
8.3.2. Year-Over-Year (Y-o-Y) Growth Analysis (%) and Market Share Analysis (%) 
8.3.3. Market Opportunity Analysis 
9.Global Downstream Processing Market  By Region, 2018-2022 and Forecast 2023-2029 (Sales Value USD Million)
9.1. North America
9.1.1. Market Analysis, 2018-2022 and Forecast, 2023-2029, (Sales Value USD Million)
9.1.2. Year-Over-Year (Y-o-Y) Growth Analysis (%) and Market Share Analysis (%) 
9.1.3. Market Opportunity Analysis 
9.2. Europe
9.2.1. Market Analysis, 2018-2022 and Forecast, 2023-2029, (Sales Value USD Million)
9.2.2. Year-Over-Year (Y-o-Y) Growth Analysis (%) and Market Share Analysis (%) 
9.2.3. Market Opportunity Analysis 
9.3. Asia Pacific (APAC)
9.3.1. Market Analysis, 2018-2022 and Forecast, 2023-2029, (Sales Value USD Million)
9.3.2. Year-Over-Year (Y-o-Y) Growth Analysis (%) and Market Share Analysis (%) 
9.3.3. Market Opportunity Analysis 
9.4. Middle East and Africa (MEA)
9.4.1. Market Analysis, 2018-2022 and Forecast, 2023-2029, (Sales Value USD Million)
9.4.2. Year-Over-Year (Y-o-Y) Growth Analysis (%) and Market Share Analysis (%) 
9.4.3. Market Opportunity Analysis 
9.5. Latin America
9.5.1. Market Analysis, 2018-2022 and Forecast, 2023-2029, (Sales Value USD Million)
9.5.2. Year-Over-Year (Y-o-Y) Growth Analysis (%) and Market Share Analysis (%) 
9.5.3. Market Opportunity Analysis 
10.North America Downstream Processing Market ,2018-2022 and Forecast 2023-2029 (Sales Value USD Million)
10.1. Product Type Analysis 2018-2022 and Forecast 2023-2029 by Sales Value USD Million, Y-o-Y Growth (%), and Market Share (%) 
10.1.1.Membrane Adsorbents
10.1.2.Chromatography Columns and Resins
10.1.3.Filters
10.1.4.Others
10.2.  Technique Analysis 2018-2022 and Forecast 2023-2029 by Sales Value USD Million, Y-o-Y Growth (%), and Market Share (%) 
10.2.1.Purification Techniques
10.2.2.Concentration/Clarification
10.3.  Application Analysis 2018-2022 and Forecast 2023-2029 by Sales Value USD Million, Y-o-Y Growth (%), and Market Share (%) 
10.3.1.Vaccine Production
10.3.2.Monoclonal Antibodies Production
10.3.3.Insulin Production
10.3.4.Erythropoietin Production
10.3.5.Immunoglobulin Production
10.3.6.Others
10.4.  End User Analysis 2018-2022 and Forecast 2023-2029 by Sales Value USD Million, Y-o-Y Growth (%), and Market Share (%) 
10.4.1.Biopharmaceutical Manufacturers
10.4.2.Contract Manufacturing Organizations
10.4.3.Others
10.5.  Country Analysis 2018-2022 and Forecast 2023-2029 by Sales Value USD Million, Y-o-Y Growth (%), and Market Share (%) 
10.5.1.United States of America (USA)
10.5.2.Canada
11.Europe Downstream Processing Market ,2018-2022 and Forecast 2023-2029 (Sales Value USD Million)
11.1. Product Type Analysis  and Forecast  by Sales Value USD Million, Y-o-Y Growth (%), and Market Share (%) 
11.1.1.Membrane Adsorbents
11.1.2.Chromatography Columns and Resins
11.1.3.Filters
11.1.4.Others
11.2.  Technique Analysis 2018-2022 and Forecast 2023-2029 by Sales Value USD Million, Y-o-Y Growth (%), and Market Share (%) 
11.2.1.Purification Techniques
11.2.2.Concentration/Clarification
11.3.  Application Analysis 2018-2022 and Forecast 2023-2029 by Sales Value USD Million, Y-o-Y Growth (%), and Market Share (%) 
11.3.1.Vaccine Production
11.3.2.Monoclonal Antibodies Production
11.3.3.Insulin Production
11.3.4.Erythropoietin Production
11.3.5.Immunoglobulin Production
11.3.6.Others
11.4.  End User Analysis 2018-2022 and Forecast 2023-2029 by Sales Value USD Million, Y-o-Y Growth (%), and Market Share (%) 
11.4.1.Biopharmaceutical Manufacturers
11.4.2.Contract Manufacturing Organizations
11.4.3.Others
11.5.  Country Analysis 2018-2022 and Forecast 2023-2029 by Sales Value USD Million, Y-o-Y Growth (%), and Market Share (%) 
11.5.1.Germany
11.5.2.France
11.5.3.Italy
11.5.4.United Kingdom (UK)
11.5.5.Spain
11.5.6.Rest of EU
11.5.7.
12.Asia Pacific (APAC) Downstream Processing Market ,2018-2022 and Forecast 2023-2029 (Sales Value USD Million)
12.1. Product Type Analysis  and Forecast  by Sales Value USD Million, Y-o-Y Growth (%), and Market Share (%) 
12.1.1.Membrane Adsorbents
12.1.2.Chromatography Columns and Resins
12.1.3.Filters
12.1.4.Others
12.2.  Technique Analysis 2018-2022 and Forecast 2023-2029 by Sales Value USD Million, Y-o-Y Growth (%), and Market Share (%) 
12.2.1.Purification Techniques
12.2.2.Concentration/Clarification
12.3.  Application Analysis 2018-2022 and Forecast 2023-2029 by Sales Value USD Million, Y-o-Y Growth (%), and Market Share (%) 
12.3.1.Vaccine Production
12.3.2.Monoclonal Antibodies Production
12.3.3.Insulin Production
12.3.4.Erythropoietin Production
12.3.5.Immunoglobulin Production
12.3.6.Others
12.4.  End User Analysis 2018-2022 and Forecast 2023-2029 by Sales Value USD Million, Y-o-Y Growth (%), and Market Share (%) 
12.4.1.Biopharmaceutical Manufacturers
12.4.2.Contract Manufacturing Organizations
12.4.3.Others
12.5.  Country Analysis 2018-2022 and Forecast 2023-2029 by Sales Value USD Million, Y-o-Y Growth (%), and Market Share (%) 
12.5.1.China
12.5.2.India
12.5.3.Australia and New Zealand (ANZ)
12.5.4.Japan
12.5.5.Rest of APAC
13.Middle East and Africa (MEA) Downstream Processing Market ,2018-2022 and Forecast 2023-2029 (Sales Value USD Million)
13.1. Product Type Analysis  and Forecast  by Sales Value USD Million, Y-o-Y Growth (%), and Market Share (%) 
13.1.1.Membrane Adsorbents
13.1.2.Chromatography Columns and Resins
13.1.3.Filters
13.1.4.Others
13.2.  Technique Analysis 2018-2022 and Forecast 2023-2029 by Sales Value USD Million, Y-o-Y Growth (%), and Market Share (%) 
13.2.1.Purification Techniques
13.2.2.Concentration/Clarification
13.3.  Application Analysis 2018-2022 and Forecast 2023-2029 by Sales Value USD Million, Y-o-Y Growth (%), and Market Share (%) 
13.3.1.Vaccine Production
13.3.2.Monoclonal Antibodies Production
13.3.3.Insulin Production
13.3.4.Erythropoietin Production
13.3.5.Immunoglobulin Production
13.3.6.Others
13.4.  End User Analysis 2018-2022 and Forecast 2023-2029 by Sales Value USD Million, Y-o-Y Growth (%), and Market Share (%) 
13.4.1.Biopharmaceutical Manufacturers
13.4.2.Contract Manufacturing Organizations
13.4.3.Others
13.5.  Country Analysis 2018-2022 and Forecast 2023-2029 by Sales Value USD Million, Y-o-Y Growth (%), and Market Share (%) 
13.5.1.GCC Countries
13.5.2.South Africa
13.5.3.Rest of MEA
14.Latin America Downstream Processing Market ,2018-2022 and Forecast 2023-2029 (Sales Value USD Million)
14.1. Product Type Analysis  and Forecast  by Sales Value USD Million, Y-o-Y Growth (%), and Market Share (%) 
14.1.1.Membrane Adsorbents
14.1.2.Chromatography Columns and Resins
14.1.3.Filters
14.1.4.Others
14.2.  Technique Analysis 2018-2022 and Forecast 2023-2029 by Sales Value USD Million, Y-o-Y Growth (%), and Market Share (%) 
14.2.1.Purification Techniques
14.2.2.Concentration/Clarification
14.3.  Application Analysis 2018-2022 and Forecast 2023-2029 by Sales Value USD Million, Y-o-Y Growth (%), and Market Share (%) 
14.3.1.Vaccine Production
14.3.2.Monoclonal Antibodies Production
14.3.3.Insulin Production
14.3.4.Erythropoietin Production
14.3.5.Immunoglobulin Production
14.3.6.Others
14.4.  End User Analysis 2018-2022 and Forecast 2023-2029 by Sales Value USD Million, Y-o-Y Growth (%), and Market Share (%) 
14.4.1.Biopharmaceutical Manufacturers
14.4.2.Contract Manufacturing Organizations
14.4.3.Others
14.5.  Country Analysis 2018-2022 and Forecast 2023-2029 by Sales Value USD Million, Y-o-Y Growth (%), and Market Share (%) 
14.5.1.Brazil
14.5.2.Mexico
14.5.3.Rest of LA
15. Competition Landscape
15.1.  Market Player Profiles (Introduction, Brand/Product Sales, Financial Analysis, Product Offerings, Key Developments, Collaborations, M & A, Strategies, and SWOT Analysis) 
15.2.1.Boehringer Ingelheim GmbH (Germany)
15.2.2.3M Company (U.S.)
15.2.3.Eppendorf AG (Germany)
15.2.4.Danaher Corporation (U.S.)
15.2.5.General Electric (U.S.)
15.2.6.Finesse Solutions, Inc. (Thermo Fisher Scientific) (U.S.)
15.2.7.Merck KGaA (Germany)
15.2.8.Lonza Group AG (Switzerland)
16. Research Methodology 
17. Appendix and Abbreviations 
  • Boehringer Ingelheim GmbH (Germany)
  • 3M Company (U.S.)
  • Eppendorf AG (Germany)
  • Danaher Corporation (U.S.)
  • General Electric (U.S.)
  • Finesse Solutions, Inc. (Thermo Fisher Scientific) (U.S.)
  • Merck KGaA (Germany)
  • Lonza Group AG (Switzerland)

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