Interferon-gamma is a dimerized soluble cytokine and the only member of type II class of interferons. IFNγ plays a role in regulating the immune response of its target cell; in both innate and adaptive immunity, its expression is upregulated and downregulated by the cytokines. Activating cell signaling pathways can promote inflammation, antiviral antibacterial activity, cell proliferation, and differentiation. Dysregulated IFNγ expression is associated with several autoinflammatory and autoimmune diseases. IFNγ inhibitors act by binding and neutralizing IFNγ. Their specific interaction with IFNγ inhibits the interaction between interferon-gamma and its cognate receptor on T-cells, producing the neutralizing activity. IFNγ inhibitors treat haemophagocytic lymphohistiocytosis. SOBI, UNION Therapeutics, Amgen, Kiora Pharma, Hanmi Pharmaceutical, Shanghai Pharma, and AprilBio are major players in the IFNγ inhibitors market.
Key Market Developments:
- In Jan 2023, UNION Therapeutics, Orismilast received Fast Track status from the US FDA for hidradenitis suppurativa.
- In Mar 2023, AB2 Bio planned to submit a marketing authorization application for Tadekinig alfa.
Approved Drug Molecules and Brand Names for IFNγ Inhibitors:
- Gamifant (Emapalumab-lzsg)
Drugs under the Pipeline for IFNγ Inhibitors:
- Orismilast oral (LEO 32731)
- Vidofludimus (IMU-838)
- Tadekinig alfa (IL-18BP)
- AMG 811
- KIO-101
- LAPS-IFNα (HM10660A)
- 5-Hydroxytriptolide
- APB-R3
- EI-001
- SFA-002
- Orismilast topical (LEO 32731 topical)
Clinical Activity and Developments of IFNγ Inhibitors:
Currently, there are 12 drug products in the IFNγ inhibitors, including one approved drug product and the rest of them are in the clinical development phases.
- In Jan 2023, UNION Therapeutics released top-line efficacy and safety data from phase-IIb clinical trials in plaque psoriasis for Orismilast.
- In Feb 2023, Syneos Health and AprilBio planned a phase-I trial for adult-onset Still’s disease in Australia for APB-R3, an IFNγ inhibitor.
|
Molecule Name |
Number of Studies |
|
Orismilast oral (LEO 32731) |
12 |
|
Vidofludimus (IMU-838) |
12 |
|
Tadekinig alfa (IL-18BP) |
5 |
|
AMG 811 |
4 |
|
KIO-101 |
3 |
|
LAPS-IFNα (HM10660A) |
2 |
|
5-Hydroxytriptolide |
1 |
|
APB-R3 |
1 |
|
EI-001 |
1 |
|
SFA-002 |
1 |
|
Orismilast topical (LEO 32731 topical) |
1 |
Target Indication Analysis of IFN-Gamma Inhibitors
IFNγ inhibitor Emapalumab is indicated for the treatment of patients with primary hemophagocytic lymphohistiocytosis, is in phase-II/III for COVID 19 infections, and in phase-II for transplant rejection. Other IFNγ inhibitors are being investigated for conditions such as multiple sclerosis, Crohn’s disease, ulcerative colitis, immunological disorders, adult-onset Still’s disease, and others.
Regional Analysis of IFN-Gamma Inhibitors
IFN Inhibitors Market
SOBI’s Gamifant had a total revenue of USD 86 million in 2022 with a 6% increase from the previous year’s sales. According to the comprehensive data from the Swedish National Registry, yearly haemophagocytic lymphohistiocytosis has incidence cases of 1.5 million, and in pediatric patients, estimated incidence rate is as high as 1 in 3,000. The autoimmune diseases affect as much as 4.5 percent of the world’s population. According to the Autoimmune Registry Inc (ARI) report 2020, about 15 to 30 million people in the USA suffer from autoimmune disease, which primarily affects women aged 20 to 40. The growing burden of related diseases indicates the market growth potential for IFNγ inhibitors.
Latin America
Europe
Asia Pacific
Middle East
North America
Frequently Asked Questions
Gamifant (Emapalumab-lzsg) approved IFN-Gamma inhibitors in the market.
SOBI, UNION Therapeutics, Amgen, Kiora Pharma, Hanmi Pharmaceutical, Shanghai Pharma, and AprilBio are some of the major players in the IFN-Gamma inhibitors market.
Major indications for IFN-Gamma inhibitor is haemophagocytic lymphohistiocytosis.
There are a total of 11 molecules in the clinical development phases for IFN-Gamma inhibitors.
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