Immune checkpoints are a part of the immune system which prevents immune response that destroys healthy cells in the body. They engage with proteins on the surface of T-cells and bind to partner proteins on other cells and form immune checkpoint proteins. When the checkpoint and partner proteins bind together, they send an off signal to the T cells, which could prevent the immune system from destroying cancer cells. Immune checkpoint inhibitors bind with high affinity to the cell surface receptor programmed cell death protein 1 (PD-1) and antagonize its interaction with its known ligands PD-L1 and PD-L2, which prevents the inhibition of the TCR-mediated T-cell proliferation and cytokine production, causing a physiological shift towards immune reactivity and enhancing tumor immunosurveillance and anti-tumor immune response. Immune checkpoint inhibitors are indicated for melanoma, non-small cell lung cancer, head and neck cancer, hodgkin’s lymphoma, B-cell lymphomas, urothelial carcinoma, gastric cancer, esophageal cancer, cervical cancer, and others. Novartis, Merck (MSD), Ono Pharma, BMS, AstraZeneca, BeiGene, Gilead Sciences, Roche, GSK, and Eli Lilly & Company are some of the major players in the Immune checkpoint inhibitors market.
Key Market Developments:
Approved Drug Molecules and Brand Names for Immune Checkpoint Inhibitors:
Drugs under the Pipeline for Immune Checkpoint Inhibitors:
Clinical Activity and Developments of Immune Checkpoint Inhibitors:
Currently, there are more than 700 drug products in the immune checkpoint inhibitors, including 24 approved drug products and the rest of them are in the clinical development phases.
Molecule Name |
Number of Studies |
Imjudo (Tremelimumab) |
126 |
Tiragolumab (RG6058) |
49 |
Relatlimab (BMS-986016) |
45 |
APL-502 |
34 |
Bintrafusp alfa (M7824) |
34 |
Zynyz (Retifanlimab-dlwr) |
33 |
Retlirafusp alfa (SHR-1701) |
27 |
Spartalizumab (PDR001) |
27 |
Adebrelimab (SHR-1316) |
25 |
Magrolimab (GS-4721) |
25 |
Balstilimab (AGEN2034) |
21 |
Ezabenlimab (BI 754091) |
20 |
Ivonescimab (AK112) |
20 |
Puyouheng (Pucotenlimab) |
19 |
Vibostolimab/Pembrolizumab (MK-7684A) |
17 |
Favezelimab/Pembrolizumab (MK-4280A) |
16 |
Sabatolimab (MBG453) |
16 |
Domvanalimab (AB154) |
15 |
Epacadostat (INCB024360) |
15 |
Erfonrilimab (KN046) |
15 |
Iparomlimab/Tuvonralimab (PSB205) |
15 |
Caffeine citrate |
14 |
Cetrelimab (JNJ-63723283) |
14 |
Ociperlimab (BGB-A1217) |
14 |
MK-4830 |
13 |
Etrumadenant (AB928) |
13 |
Immune checkpoint inhibitors such as Pembrolizumab, Nivolumab, Atezolizumab, Durvalumab, Tislelizumab and others are primarily indicated for the treatment of melanoma, non-small cell lung cancer, head and neck cancer, hodgkin’s lymphoma, primary mediastinal large B-cell lymphoma, gastric cancer, esophageal cancer, cervical cancer, hepatocellular carcinoma, Merkel cell carcinoma, renal cell carcinoma, endometrial carcinoma, cutaneous squamous cell carcinoma, triple-negative breast cancer, others. Moreover, there are numerous drugs in the clinical trial phases for other cancerous conditions.
Keytruda (Pembrolizumab), Opdivo (Nivolumab), Tecentriq (Atezolizumab), Imfinzi (Durvalumab), Baizean (Tislelizumab), Yervoy (Ipilimumab) are some of the approved immune checkpoint inhibitors.
Novartis, Merck (MSD), Ono Pharma, BMS, AstraZeneca, BeiGene, Gilead Sciences, Roche, GSK, and Eli Lilly & Company are some of the major players in the immune checkpoint inhibitors market.
Major indications for immune checkpoint inhibitors are melanoma, non-small cell lung cancer, head and neck cancer, hodgkin’s lymphoma, primary mediastinal large B-cell lymphoma, gastric cancer, esophageal cancer, cervical cancer, and hepatocellular carcinoma.
There are more than 700 molecules in the clinical development phases for immune checkpoint inhibitors.