RIPK1 Inhibitor Market: By Product Type (Mono and Combination), By Molecule (Peptide, Polymer, and Small Molecule), By Route of Administration (Intravenous, Intramuscular, and Subcutaneous), and Geography

RIPK1 Inhibitor Market is anticipated to grow at a 32.7% CAGR from 2024 to 2030. RIPK1 also known as Receptor-Interacting Protein Kinase-1 blocks the increased production of auto-inflammatory cytokines, it is the key mediator of apoptotic and necrotic cell death as well as inflammatory pathways useful for the treatment of acute kidney injury. Several existing multitargeting tyrosine kinase inhibitors, such as sorafenib, ponatinib, and pazopanib, show strong RIPK1 off-target effects that raise the overall market.

According to the American Kidney Fund, 37 million Americans have kidney disease. Nearly 810,000 Americans are living with kidney failure. Kidney disease is growing at an alarming rate. It currently affects more than 1 in 7 or 15% of American adults, with people of color at greater risk for kidney failure, increasing prevalence of acute kidney disorder drives the market. RIPK1 as a lifesaving treatment propelling the market for the dialysis segment, increasing geriatric population, and government initiatives for treatment consequences creating various opportunities in the RIPK1 inhibitors market. The high cost of treatment through RIPK1 drugs hinders the growth of the market, emerging countries and unstable economies hamper the market growth are the major restraints in the market. Geographically, North America held the major market share in 2022 and is expected to dominate the RIPK1 market in the forecasted years due to the increasing incidence of kidney injury patients and large spending on healthcare infrastructure.

RIPK1 Inhibitor Market Key Developments:

• In May 2022, Denali Therapeutics Announces Achievement of RIPK1 Milestone for Phase 2 Clinical Trial Initiation in ALS by Sanofi.
• In February 2021, Eli Lilly and Company and Rigel Pharmaceuticals, Inc. announced a global exclusive license agreement and strategic collaboration to co-develop and commercialize Rigel's R552, a receptor-interacting serine/threonine-protein kinase 1 (RIPK1) inhibitor, for all indications including autoimmune and inflammatory diseases.