Sample Preparation Market Size, Share, Growth, Trends, and Global Industry Analysis: By Product (Sample-Preparation Instruments, Consumables, Sample-Preparation Kits, and Accessories & Software), By Technology (Manual, Semi-Automated, and Fully Automated), By Application (Genomics, Proteomics, Epigenomics, Transcriptomics, Metabolomics, and Others), By End-Use Industry (Pharmaceutical Companies, Biotechnology Companies, Molecular Diagnostics Labs, Academic & Research Institutes, and CROs & CDMOs), and Region Forecast 2020-2031

Sample Preparation Market size was valued at US$ 7,277.1 million in 2024 and is expected to reach US$ 10,656.3 million by 2031, growing at a significant CAGR of 5.6% from 2025-2031. Moreover, the U.S. market is projected to grow significantly, reaching an estimated value of US$ 3,324.8 Million by 2031.

The global market is an industry involving products and processes used to prepare biological and chemical samples for subsequent analysis, primarily to detect or determine the presence of unwanted materials in raw materials or final products. The global market is primarily driven by the rising demand for accurate and efficient diagnostics, particularly due to the growing burden of chronic and infectious diseases. As precision medicine and high-throughput testing become the norm, laboratories are turning to automated sample preparation systems to ensure reproducibility, reduce human error, and improve turnaround time. This demand is further fueled by the expansion of molecular diagnostics, genomics, and proteomics. A key trend reshaping the market is the adoption of automation and miniaturization, including microfluidic technologies and lab-on-a-chip platforms that allow for faster and more precise analysis with smaller sample volumes. These advancements support decentralized testing, real-time analytics, and sustainability goals through eco-friendly prep methods.

The biggest opportunity lies in the rising momentum for personalized diagnostics, especially in oncology, rare disease detection, and companion diagnostics, where high-quality sample prep is vital. However, the market faces restraints in the form of high capital costs for automated systems and proprietary reagents, particularly in resource-constrained regions. Additionally, a lack of skilled personnel and variability in protocol standardization further challenge adoption. Despite these limitations, continued innovation in automation, cloud integration, and universal prep kits indicates a strong outlook for smarter, faster, and more accessible sample preparation solutions globally.

Facts & Figures

• Rising Demand for Precision Diagnostics: The growing burden of chronic and infectious diseases has intensified the demand for accurate, early-stage diagnostic tools. Sample preparation plays a foundational role in isolating and purifying biomarkers from complex biological matrices (blood, saliva, tissues) to ensure reliable test results. For instance, according to the WHO 2024 report, global diagnostic volumes have surged by over 20% since COVID-19, with molecular testing leading the charge. Sample preparation tools are increasingly bundled into diagnostic platforms by companies like Roche and Qiagen.
• Expansion in Pharmaceutical R&D and Clinical Trials: As pharmaceutical pipelines grow, especially in biologics and personalized therapeutics, the need for robust sample preparation in biomarker discovery, toxicology, and pharmacokinetics intensifies. High-quality sample prep enables cleaner data and reproducible results in analytical workflows. For instance, IQVIA’s 2024 Global R&D Report revealed that pharma R&D spending hit $258 billion, with 35% allocated to clinical research operations, where sample prep is integral to lab workflows.
• Growth in Genomics, Proteomics & Omics-Based Research: With the rising adoption of next-generation sequencing (NGS), transcriptomics, and proteomics, laboratories require highly reproducible sample preparation techniques. The quality of prepared samples significantly influences data accuracy and reproducibility, essential in biomarker discovery and precision medicine. For instance, the NIH’s budget allocation for 2024 includes over $2.7 billion for omics research. GlobalData shows that over 60% of NGS-related lab errors stem from inadequate sample prep-prompting companies to invest in automated, contamination-free systems.
• Increasing Lab Automation and Throughput Needs: Modern labs face rising workloads and shorter turnaround time expectations, especially in clinical settings. To cope, institutions are increasingly automating their sample prep processes using robotic liquid handlers, automated centrifuges, and barcode-integrated tracking systems. For instance, according to Thermo Fisher and Agilent Technologies' annual reports, they achieved double-digit growth in automated sample preparation systems in 2023. The trend is especially visible in diagnostic mega-labs, which process thousands of samples daily.

Recent Developments

• In July 2025, Dash Bio, founded by former Moderna executives, secured $11 million through seed funding to scale an AI-robotics platform designed to automate bioanalysis from clinical and animal study samples, reducing drug development timeframes.
• In May 2025, QIAGEN acquired Genoox for US?$70M, integrating its AI-powered clinical genomics platform Franklin into the QIAGEN Digital Insights portfolio. This enhances lab scalability and NGS interpretation efficiency for hereditary and oncology testing.
• In April 2025, Siemens agreement to acquire Dotmatics (R&D informatics and lab automation software) expands digital laboratory orchestration capabilities, enabling tighter integration with sample prep systems.
• In February 2025, Waters Corporation is to merge with Becton Dickinson’s Bioscience Unit for US$17.5B in mid-2025 for lab instrumentation and diagnostics, strengthening automation and analytical workflows, including sample processing.        

Sample Preparation Market Segmentation

Based on the product

• Sample-Preparation Instruments
  • Extraction Systems
  • Automated Workstations
  • Evaporation Systems
  • Liquid-Handling Platforms
  • Other Instruments
• Consumables
  • Sample-Preparation Kits
  • Purification Kits Isolation Kits
  • Extraction Kits
• Accessories & Software

The sample-preparation instruments hold the largest market share, driven by their critical role in automating and standardizing complex lab workflows across genomics, proteomics, and diagnostics. Instruments like centrifuges, robotic liquid handlers, and automated purification systems enhance throughput, reduce contamination risks, and deliver reproducible results, making them indispensable in high-volume laboratories and clinical research centers. Their demand surged especially post-COVID, as labs scaled up molecular testing capacities. Increasing adoption in pharmaceutical R&D and academic institutions also fuels growth. On the other hand, accessories and software, while important for supporting system performance, currently hold the smallest share due to their lower standalone value and limited usage scope.

Based on the technology

• Manual
• Semi-Automated
• Fully Automated

In the global sample preparation market, fully automated technologies dominate in terms of market share due to their unmatched efficiency, consistency, and scalability. These systems are widely adopted in high-throughput laboratories handling genomics, proteomics, and clinical diagnostics, where speed and accuracy are critical. Fully automated systems reduce human error, minimize contamination, and significantly increase productivity, especially vital for applications like next-generation sequencing (NGS) and liquid biopsy. The demand for automation further accelerated after the COVID-19 pandemic due to increased sample volumes and workforce limitations. Meanwhile, manual sample preparation, though still used in low-resource or academic labs for basic tasks, holds the smallest market share due to limitations in scalability and precision.

Based on the application

• Genomics
• Proteomics
• Epigenomics
• Transcriptomics
• Metabolomics
• Others

Genomics holds the largest market share in the global sample preparation market. This dominance is driven by the widespread adoption of next-generation sequencing (NGS), growing investments in precision medicine, and the increasing need for DNA/RNA extraction in genetic testing and disease diagnosis. Genomics-based applications are pivotal in oncology, rare disease research, and population genomics programs, especially in regions like North America and the Asia-Pacific. The demand for high-throughput, automated sample prep solutions is particularly high in genomics due to the volume and sensitivity of samples. In contrast, epigenomics remains the smallest segment, primarily due to its niche research applications and relatively limited clinical adoption at present.

Based on the end-use industry

• Pharmaceutical Companies
• Biotechnology Companies
• Molecular Diagnostics Labs
• Academic & Research Institutes
• CROs & CDMOs

The pharmaceutical companies hold the largest market share due to their extensive reliance on high-quality, reproducible sample prep processes in drug discovery, clinical trials, and quality control. With increasing R&D investments, the demand for automated and standardized sample handling, especially for small molecule analysis and biomarker validation, continues to grow. Additionally, the rise of biologics and personalized medicines is further amplifying pharma's dependence on advanced sample preparation tools. However, CROs & CDMOs occupy the smallest share, though their market is expanding as more pharma companies outsource R&D and testing functions.