USA Photodynamic Therapy Market Size, Share, Growth, Trends, and Industry Analysis: By Product, By Indication, By End User and Country Forecast 2020-2031

USA Photodynamic Therapy Market Size, Share, Growth, Trends, and Industry Analysis: By Product (Photodynamic Therapy Devices, Photosensitizer Drugs), By Indication (Cancer, Actinic Keratosis, Acne, Psoriasis, Others), By End User (Hospitals, Cancer Treatment Centers, Cosmetic and Dermatology Clinics, Others) and Country Forecast 2020-2031

USA Photodynamic Therapy market size was valued at US$ 1,076.3 million in 2024 and is projected to reach US$ 1,762.5 million by 2031, growing at a CAGR of 7.3% from 2025-2031. The market is experiencing steady growth, driven by the rising cancer and skin disorders prevalence. With almost 2 million new cancer cases and 611,720 cancer fatalities anticipated in 2024, the need for cutting-edge treatments such as PDT is on the rise. The targeted precision of PDT with minimal invasiveness places it as the first option in treating conditions like skin cancer, actinic keratosis, and acne.

Furthermore, growing patient and provider awareness of the advantages of PDT, including shorter recovery times and fewer side effects, fosters uptake. In addition, technologically advanced photosensitizers and illumination devices such as lasers and LEDs are improving efficacy and broadening applications for PDT. The major players in the industry and solid healthcare infrastructure add further impetus to market expansion. Costly treatments and lack of access in rural settings hinder market growth. Nevertheless, government policies and research grants encourage innovation, and collaborations between healthcare organizations and industry are hastening progress. The USA continues to be a strong force in the world PDT market, with vast growth opportunities in oncology and dermatology uses.

Key Takeaways

  • The U.S. Photodynamic Therapy market is witnessing significant growth in the Photodynamic Therapy Devices segment, which was valued at US$ xx billion in 2024 with a share of xx%.
  • The Cancer segment is a major contributor to the cold storage market, with a share of xx% and was valued at US$ xx Billion in 2024.

Key Developments

  • In June 2024, Biofrontera Inc. placed its 100th RhodoLED® XL Lamp in the US, following FDA approval for use with Ameluz® gel in treating actinic keratoses. The lamp's enhanced LED panels improve efficiency and patient throughput. Physicians can now use up to three Ameluz® tubes, optimizing large-area treatments effectively.
  • In March 2022: Biofrontera Inc. previously secured U.S. patent No. 11,235,169 for its BF-RhodoLED XL illumination device. The company has confirmed its inclusion in the FDA's "Approved Drug Products with Therapeutic Equivalency Evaluations," commonly known as the Orange Book.

The USA Photodynamic Therapy Market  Segmentation

Based on the product the market

  • Photodynamic Therapy Devices
  • Photosensitizer Drugs

Photosensitizer Drugs dominate the Photodynamic Therapy market due to their crucial role in initiating the treatment process. These drugs, activated by specific light wavelengths, generate reactive oxygen species to target and destroy abnormal cells. Their clinical effectiveness, regulatory approvals, and expanding use in treating cancers and dermatological disorders drive their market dominance.

Based on the indication

  • Cancer
  • Actinic Keratosis
  • Acne
  • Psoriasis
  • Others

Cancer is the leading segment in the Photodynamic Therapy market due to the global rise in cancer prevalence, with nearly 10 million deaths annually (WHO, 2020). PDT's effectiveness in treating early-stage and drug-resistant cancers, along with its minimal invasiveness and reduced side effects, drives its widespread adoption in oncology treatments.

Based on the end-user

  • Hospitals
  • Cancer Treatment Centers
  • Cosmetic and Dermatology Clinics
  • Others

Hospitals dominate the Photodynamic Therapy market as they offer advanced infrastructure and comprehensive care for oncology and dermatology treatments. Their ability to handle high patient volumes, coupled with access to cutting-edge technology and skilled professionals, positions them as the primary end user for effective PDT applications globally.

USA Photodynamic Therapy Market Dynamics

Drivers

Several factors drive the U.S. Photodynamic Therapy (PDT) market. Increasing cancer cases, with almost 2 million new diagnoses every year, drive the demand for new treatments such as PDT. Skin conditions such as actinic keratosis and acne also drive the market growth. Technological advances such as better photosensitizers and targeted light delivery systems make PDT more efficient and applicable the availability of key industry players and strong healthcare infrastructure support market growth. Furthermore, growing patient and healthcare professional awareness of the advantages of PDT, including minimal invasiveness and less recovery time, supports popularity. Government programs and research grants also support innovation, and partnerships between healthcare professionals and industry players support the development of PDT solutions throughout the U.S. healthcare system.

Restraints

The U.S. Photodynamic Therapy (PDT) market faces several restraints hindering its growth. The expensive treatment cost continues to be a significant restraint, limiting patient access, especially in rural and poor areas. Physicians' and patients' insufficient awareness of the benefits and applications of PDT still discourages its utilization. Further, the treatment is specialized and requires training and expertise, and the lack of trained practitioners is a barrier to its usage. Side effects, though temporary, such as pain, erythema, and visual changes, can discourage patients from pursuing PDT. In addition, regulatory issues and approval, which take time for new photosensitizers and devices, can discourage market expansion. All these must be tackled to realize the maximum potential for PDT in America.

Opportunities

The U.S. Photodynamic Therapy (PDT) market offers significant opportunities for growth and innovation. The rise in drug-resistant skin diseases and cancers provides a need for next-generation, least-invasive treatments like PDT. Advances in the mode of nanotechnology-based photosensitizers and more sophisticated light delivery systems improve precision and widen the treatment window. The evolution of research using PDT for non-oncology diseases, e.g., age-related macular degeneration, promotes its usage. Government policies and investment support healthcare innovation, driving market growth. Partnerships among healthcare institutions, health systems, and industry stakeholders guarantee innovation in PDT solutions. Furthermore, increasing patient and caregiver knowledge of the advantages of PDT, such as shorter recovery times and fewer side effects, promotes adoption, with the U.S. leading the charge.

Trends

The U.S. Photodynamic Therapy (PDT) market is witnessing several key trends. The application of new photosensitizers, including nanotechnology-based agents, is raising the specificity of treatment and indications for PDT. More application of PDT in non-oncologic conditions, including age-related macular degeneration, shows its greater versatility. Minimally invasive and outpatient procedures are becoming more popular, reflecting patient interest in less time required for recovery. The industry-clinician partnership drives innovation, with government programs and grants supporting research development. Increased awareness among patients and providers of the advantages of PDT, including fewer side effects, is driving adoption. Electronic technology use, e.g., iPad-controlled lasers, is one example of market focus on simple-to-use and practical solutions. All these trends combined are part of their contribution to legitimizing PDT's place in today's healthcare.

U S Photodynamic Therapy Market Segmentation Analysis

Report Benchmarks

Details

Market Size in 2024

US$ 1,076.3 million

Market Size in 2031

US$ 1,762.5 million

By Product

  • Photodynamic Therapy Devices
  • Photosensitizer Drugs

By Indication

  • Cancer
  • Actinic Keratosis
  • Acne
  • Psoriasis
  • Others

By End User

  • Hospitals
  • Cancer Treatment Centers
  • Cosmetic and Dermatology Clinics
  • Others

Analyst Review

The USA Photodynamic Therapy Market expanded from USD xx billion in 2020 to USD xx billion in 2024 and is expected to reach USD xx billion by 2031, registering a xx% CAGR driven by stringent FDA regulations and increasing demand for innovative, minimally invasive treatments. PDT’s effectiveness in treating cancers and skin disorders and advancements in photosensitizers and light delivery systems enhance its adoption. The market benefits from technological innovations, such as AI-based analytics and IoT-enabled monitoring, which improve treatment precision and patient outcomes.

The growing prevalence of cancer and skin conditions, along with rising awareness among healthcare providers and patients, further propels market expansion. In addition, government initiatives and research funding foster innovation, while collaborations between healthcare institutions and industry players accelerate advancements in PDT solutions. However, challenges like high treatment costs and limited accessibility in rural areas persist. Despite these, the market is poised for long-term growth, supported by regulatory mandates, continuous technological advancements, and expanding applications in oncology and dermatology.

Key Features of the Report

  • The USA photodynamic therapy market report provides granular level information about the market size, region market share, historic market (2020-2024), and forecast (2025-2031)
  • The report covers in-detail insights about the competitor’s overview, company share analysis, key market developments, and key strategies.
  • The report outlines drivers, restraints, unmet needs, and trends that are currently affecting the market.
  • The report tracks recent innovations, key developments, and start-up details that are actively working in the market.
  • The report provides a plethora of information about Market entry strategies, regulatory framework, and reimbursement scenarios.
  • The report analyses the impact of the socio-political environment through PESTLE Analysis and competition through Porter's Five Force Analysis.

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Frequently Asked Questions

USA Photodynamic Therapy market size was valued at US$ 1,076.3 million in 2024 and is projected to reach US$ 1,762.5 million by 2031, growing at a CAGR of 7.3% from 2025-2031.

• Rising Cancer Incidence
• Advancements in PDT Technology
• Demand for Minimally Invasive Treatments.

• Advancements in Photosensitizers • Combination Therapies

The USA Photodynamic Therapy Market size includes several companies, such as Biofrontera AG, Excel Lasers Limited, Galderma Laboratories, Modulight Corporation, Theralase Technologies Inc., LUMIBIRD Group (Quantel Medical), SUS Advancing Technology Co., Ltd, and others.

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Author

Muni Kumar Meravath

Muni Kumar Meravath is a seasoned Healthcare Market Research Analyst with over 6 years of experience in the healthc.....

1. Executive Summary
2. USA Photodynamic Therapy Market Introduction
2.1. USA Photodynamic Therapy Market Taxonomy
2.2. USA Photodynamic Therapy Market Definitions
2.2.1. By Product
2.2.2. By Indication
2.2.3. By End User
3. USA Photodynamic Therapy Market Dynamics
3.1. Drivers
3.2. Restraints
3.3. Opportunities/Unmet Needs of the Market
3.4. Trends
3.5. USA Photodynamic Therapy Market Dynamic Factors - Impact Analysis
3.6. USA Photodynamic Therapy Market Competition Landscape
4. USA Photodynamic Therapy Market Analysis,2020 - 2024 and Forecast, 2025 - 2031
4.1. Market Analysis,2020 - 2024 and Forecast, 2025 - 2031 (Revenue, USD Mn)
4.2. Year-over-Year (Y-o-Y) Growth Analysis (%)
4.3. Market Opportunity Analysis
5. USA Photodynamic Therapy Market, By Product, 2020 - 2024 and Forecast, 2025 - 2031 (Revenue, USD Mn)
5.1. Photodynamic Therapy Devices
5.1.1.  Aminolevulinic Acid
5.1.1.1. Market Analysis, 2020 - 2024 and Forecast, 2025 - 2031 (Revenue, USD Mn)
5.1.1.2. Year-over-Year (Y-o-Y) Growth Analysis (%) and Market Share Analysis (%)
5.1.1.3. Market Opportunity Analysis
5.1.2. Porphyrin Derivatives
5.1.2.1. Market Analysis, 2020 - 2024 and Forecast, 2025 - 2031 (Revenue, USD Mn)
5.1.2.2. Year-over-Year (Y-o-Y) Growth Analysis (%) and Market Share Analysis (%)
5.1.2.3. Market Opportunity Analysis
5.1.3. Chlorines
5.1.3.1. Market Analysis, 2020 - 2024 and Forecast, 2025 - 2031 (Revenue, USD Mn)
5.1.3.2. Year-over-Year (Y-o-Y) Growth Analysis (%) and Market Share Analysis (%)
5.1.3.3. Market Opportunity Analysis
5.1.4. Others
5.1.4.1. Market Analysis, 2020 - 2024 and Forecast, 2025 - 2031 (Revenue, USD Mn)
5.1.4.2. Year-over-Year (Y-o-Y) Growth Analysis (%) and Market Share Analysis (%)
5.1.4.3. Market Opportunity Analysis
5.2. Photosensitizer Drugs
5.2.1. Diode Lasers
5.2.1.1. Market Analysis, 2020 - 2024 and Forecast, 2025 - 2031 (Revenue, USD Mn)
5.2.1.2. Year-over-Year (Y-o-Y) Growth Analysis (%) and Market Share Analysis (%)
5.2.1.3. Market Opportunity Analysis
5.2.2. Disposable Fiber Optic Light Delivery Devices
5.2.2.1. Market Analysis, 2020 - 2024 and Forecast, 2025 - 2031 (Revenue, USD Mn)
5.2.2.2. Year-over-Year (Y-o-Y) Growth Analysis (%) and Market Share Analysis (%)
5.2.2.3. Market Opportunity Analysis
6. USA Photodynamic Therapy Market, By Indication, 2020 - 2024 and Forecast, 2025 - 2031 (Revenue, USD Mn)
6.1. Cancer
6.1.1. Basal Cell Carcinoma
6.1.1.1. Market Analysis, 2020 - 2024 and Forecast, 2025 - 2031 (Revenue, USD Mn)
6.1.1.2. Year-over-Year (Y-o-Y) Growth Analysis (%) and Market Share Analysis (%)
6.1.1.3. Market Opportunity Analysis
6.1.2. Non-Small Cell Lung Cancer
6.1.2.1. Market Analysis, 2020 - 2024 and Forecast, 2025 - 2031 (Revenue, USD Mn)
6.1.2.2. Year-over-Year (Y-o-Y) Growth Analysis (%) and Market Share Analysis (%)
6.1.2.3. Market Opportunity Analysis
6.1.3. Head & Neck Cancer
6.1.3.1. Market Analysis, 2020 - 2024 and Forecast, 2025 - 2031 (Revenue, USD Mn)
6.1.3.2. Year-over-Year (Y-o-Y) Growth Analysis (%) and Market Share Analysis (%)
6.1.3.3. Market Opportunity Analysis
6.1.4. Others
6.1.4.1. Market Analysis, 2020 - 2024 and Forecast, 2025 - 2031 (Revenue, USD Mn)
6.1.4.2. Year-over-Year (Y-o-Y) Growth Analysis (%) and Market Share Analysis (%)
6.1.4.3. Market Opportunity Analysis
6.2. Actinic Keratosis
6.2.1. Market Analysis, 2020 - 2024 and Forecast, 2025 - 2031 (Revenue, USD Mn)
6.2.2. Year-over-Year (Y-o-Y) Growth Analysis (%) and Market Share Analysis (%)
6.2.3. Market Opportunity Analysis
6.3. Acne
6.3.1. Market Analysis, 2020 - 2024 and Forecast, 2025 - 2031 (Revenue, USD Mn)
6.3.2. Year-over-Year (Y-o-Y) Growth Analysis (%) and Market Share Analysis (%)
6.3.3. Market Opportunity Analysis
6.4. Psoriasis
6.4.1. Market Analysis, 2020 - 2024 and Forecast, 2025 - 2031 (Revenue, USD Mn)
6.4.2. Year-over-Year (Y-o-Y) Growth Analysis (%) and Market Share Analysis (%)
6.4.3. Market Opportunity Analysis
6.5. Others
6.5.1. Market Analysis, 2020 - 2024 and Forecast, 2025 - 2031 (Revenue, USD Mn)
6.5.2. Year-over-Year (Y-o-Y) Growth Analysis (%) and Market Share Analysis (%)
6.5.3. Market Opportunity Analysis
7. USA Photodynamic Therapy Market, By End User, 2020 - 2024 and Forecast, 2025 - 2031 (Revenue, USD Mn)
7.1. Hospitals
7.1.1. Market Analysis, 2020 - 2024 and Forecast, 2025 - 2031 (Revenue, USD Mn)
7.1.2. Year-over-Year (Y-o-Y) Growth Analysis (%) and Market Share Analysis (%)
7.1.3. Market Opportunity Analysis
7.2. Cancer Treatment Centers
7.2.1. Market Analysis, 2020 - 2024 and Forecast, 2025 - 2031 (Revenue, USD Mn)
7.2.2. Year-over-Year (Y-o-Y) Growth Analysis (%) and Market Share Analysis (%)
7.2.3. Market Opportunity Analysis
7.3. Cosmetic and Dermatology Clinics
7.3.1. Market Analysis, 2020 - 2024 and Forecast, 2025 - 2031 (Revenue, USD Mn)
7.3.2. Year-over-Year (Y-o-Y) Growth Analysis (%) and Market Share Analysis (%)
7.3.3. Market Opportunity Analysis
7.4. Others
7.4.1. Market Analysis, 2020 - 2024 and Forecast, 2025 - 2031 (Revenue, USD Mn)
7.4.2. Year-over-Year (Y-o-Y) Growth Analysis (%) and Market Share Analysis (%)
7.4.3. Market Opportunity Analysis
7.5. USA Photodynamic Therapy Market - Opportunity Analysis Index, By Product, Indication, and End User, 2024 - 2030
7.6. USA Photodynamic Therapy Market Dynamics Trends
8. Competition Landscape 
8.1. Strategic Dashboard of Top Market Players
8.2. Company Profiles (Introduction, Financial Analysis, Technology & Service Offerings, Key Developments, Strategies, and SWOT Analysis)
8.2.1. Galderma Laboratories, L.P.
8.2.2. Biofrontera AG
8.2.3.  Excel Lasers Limited
8.2.4. LUMIBIRD Group (Quantel Medical)
8.2.5. Modulight Corporation
8.2.6. Quest PharmaTech, Inc.
8.2.7. Theralase Technologies Inc.,
8.2.8. SUS Advancing Technology Co., Ltd
9. Research Methodology
10. Key Assumptions and Acronyms
 

Key Market Players

  • Galderma Laboratories,
  • Biofrontera AG
  • Excel Lasers Limited
  • LUMIBIRD Group (Quantel Medical)
  • Modulight Corporation
  • Theralase Technologies Inc.,
  • SUS Advancing Technology Co., Ltd

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