Inhibitor of Apoptosis Proteins (IAP) are a family of functionally and structurally related proteins which serve as endogenous inhibitors of programmed cell death, by blocking caspases proteins, which could lead to cancer or other effects on the cell if mutated or improperly regulated. IAPs are characterized by the presence of one or more BIR (Baculovirus IAP Repeated) domains, which is essential for the anti-apoptotic activity of IAPs as it is required for caspase binding. IAP antagonists promote cancer cell death by inhibiting IAPs. The drug molecules for IAP antagonists are in clinical trials for colorectal cancer, non-Hodgkin’s lymphoma, ovarian cancer, solid tumors, pancreatic cancer, hepatitis B, and others. Pharmaceutical companies such as Novartis, Roche, Eli Lilly, AbbVie, BeiGene, Boehringer Ingelheim, and others are doing clinical studies for IAP antagonists.
Key Market Developments:
- In Mar 2022, Cothera Bioscience received approval from the National Medical Products Administration (NMPA) for a phase-II trial in B-cell lymphoma patients for Sepantronium-Bromide (PC002).
- In Jul 2022, NexImmune announced IND clearance by the US FDA for NEXI 003, an autologous antigen-specific T cell product for the treatment of HPV-related cancers.
Drugs under the Pipeline for Inhibitor of Apoptosis Proteins (IAP) Antagonistss:
- Birinapant (IGM-9427)
- Xevinapant (Debio 1143)
- Maveropepimut-S (MVP-S)
- Sepantronium bromide (PC-002)
- GEM 640
- LCL161
- SurVaxM (SVN53-67/M57-KLH peptide vaccine)
- Veyonda (Idronoxil)
- Tolinapant (ASTX660)
- Phenoxodiol (NV06)
- APG-1387
- CINelim (Terameprocol)
- MultiTAA T cell therapy
- Gataparsen (LY2181308)
- AEG40826
- BI 891065
- CUDC-427
- IO101
- MT-601
- SL-701
- TQB3728
- ABBV-184
- BGB-24714
- GDC0152
- MANA-312
- NEXI-003
- OVM-200
- PDC*lung01
- Antisense LNA (EZN-3042)
Clinical Activity and Developments of Inhibitor of Apoptosis Proteins (IAP) Antagonists:
Currently, there are about 34 drug molecules in clinical trial phases as inhibitors of apoptosis for various cancers.
- In Nov 2022, Ascentage Pharma Group completed a phase-I trial in haematological malignancies and solid tumors in the USA for APG1387, an inhibitor of apoptosis.
- In May 2022, M.D. Anderson Cancer Center in collaboration with the National Cancer Institute and Novartis Pharmaceuticals completed a phase-II trial in Myelofibrosis patients in the USA for LCL161, a second mitochondria activator of caspases (SMAC) mimetic.
|
Molecule Name |
Number of Studies |
|
Birinapant (IGM-9427) |
15 |
|
Xevinapant (Debio 1143) |
15 |
|
Maveropepimut-S (MVP-S) |
14 |
|
Sepantronium bromide (PC-002) |
12 |
|
GEM 640 |
10 |
|
LCL161 |
10 |
|
SurVaxM (SVN53-67/M57-KLH peptide vaccine) |
10 |
|
Veyonda (Idronoxil) |
10 |
|
Tolinapant (ASTX660) |
9 |
|
Phenoxodiol (NV06) |
7 |
|
APG-1387 |
6 |
|
CINelim (Terameprocol) |
6 |
|
MultiTAA T cell therapy |
4 |
|
Gataparsen (LY2181308) |
4 |
|
AEG40826 |
2 |
|
BI 891065 |
2 |
|
CUDC-427 |
2 |
|
IO101 |
2 |
|
MT-601 |
2 |
|
SL-701 |
2 |
|
TQB3728 |
2 |
|
ABBV-184 |
1 |
|
BGB-24714 |
1 |
|
GDC0152 |
1 |
|
MANA-312 |
1 |
|
NEXI-003 |
1 |
|
OVM-200 |
1 |
|
PDC*lung01 |
1 |
|
Antisense LNA (EZN-3042) |
1 |
Target Indication Analysis of Inhibitor of Apoptosis Proteins (IAP) Antagonists
At present, IAP antagonists are in clinical trial phases, such as Medivir AB’s Birinapant is in phase-I for non-Hodgkin’s lymphoma, in phase-I/II for acute myeloid leukaemia, and hepatitis B, and in phase-II for chronic myelomonocytic leukaemia, colorectal cancer, myelodysplastic syndromes, ovarian cancer, and solod tumors. Similarly, Debiopharm’s Xevinapant is in phase-I for adenocarcinoma, colorectal cancer, non-small cell lung cancer, in phase-II for ovarian cancer, and solid tumors, and in phase-III for squamous cell cancer. Additionally, IMV’s Maveropepimut S is in phase-I for breast cancer, phase-I/II for solid tumors, and in phase-II for bladder cancer, diffuse large B cell lymphoma, fallopian tube cancer, glioblastoma, liver cancer, non-small cell lung cancer, ovarian cancer, peritoneal cancer, and urogenital cancer.
Regional Analysis of Inhibitor of Apoptosis Proteins (IAP) Antagonists
Inhibitor of Apoptosis Proteins Antagonists Market
IAP antagonists are primarily being developed for cancer therapies. According to the World Health Organization’s cancer report 2020, there were 1,92,92,789 new cases of cancer globally, in 2020. As per the International cancer data, cases of incidence will increase from 19 million in 2020 to 29 million in 2040. China had the highest (8,15,563 new cases) lung cancer incidence rate, followed by the USA (2,27, 875), and in pancreatic cancer also China (1,24,994) was in the top rank, followed by the USA (56,654) and Japan (44,307) in 2020. Ovarian cancer had the highest number of new cases in 2020 in China (55,341), followed by India (45,701), and the USA (23,820). In the case of non-Hodgkin lymphoma also the highest new cases were in China (42,709), followed by the USA (32,919), and Japan (15,239). All these growing cancer cases indicate market potential for IAP antagonists.
Latin America
Europe
Asia Pacific
Middle East
North America
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Frequently Asked Questions
Birinapant (IGM-9427), Xevinapant (Debio 1143), Maveropepimut-S (MVP-S), and Sepantronium bromide (PC-002) are some of the drugs under pipeline in the Inhibitor of Apoptosis Proteins (IAP) antagonists.
Novartis, Roche, Eli Lilly, AbbVie, BeiGene, and Boehringer Ingelheim are some of the major market players in the Inhibitor of Apoptosis Proteins (IAP) antagonists.
Major indications for Inhibitor of Apoptosis Proteins (IAP) Antagonistss are colorectal cancer, non-Hodgkin’s lymphoma, ovarian cancer, solid tumors, pancreatic cancer, and hepatitis B.
There are a total of 32 molecules in the Phase-I/II clinical development for Inhibitor of Apoptosis Proteins (IAP) Antagonists.
- Novartis AG (Switzerland)
- IGM Biosciences (USA)
- IMV Inc (USA)
- Cothera Bioscience (China)
- Noxopharm (Australia)
- Otsuka Pharmaceutical (Japan)
- Ascentage Pharma (Japan)
- Erimos Pharmaceuticals (USA)
- Eli Lilly and Company (USA)
- Boehringer Ingelheim (Germany)
- Roche (USA)
- Marker Therapeutics (USA)
- Sino Biopharm (China)
- AbbVie (USA)
- BeiGene (USA)
- NexImmune (USA)